Feverfew (Tanacetum parthenium) (TP) is a valuable medicinal plant from Asteraceae family with various pharmaceutical and therapeutic properties. To evaluate the effect of salicylic acid (SA) foliar application on the antioxidant enzymes responses of TP under salinity stress, a factorial experiment based on completely randomized design with three replicates under greenhouse conditions was conducted in Shiraz University, Iran. TP seedlings were fed with half strength Hoagland solution. Salinity was induced by NaCl and CaCl2 (2:1) at 30, 60, 90, 120, 150 and 180 mM concentrations. SA was applied at 0, 200 and 300 µM concentrations. Sugar, proline, catalase (CAT), peroxidase (POD) and ascorbic peroxidase (APX) were measured. With increasing salt levels all the traits measured was increased. The results showed that SA increased antioxidant enzymes and proline, which induced higher tolerance in the plants