The aim of this work is identification of the structure effect of amino acid Pd complex to DNA as an intracellular target. Hence novel water soluble Palladium complex, [Pd(phendione) (isobutyl glycine)]NO3 have been synthesized and characterized by spectroscopic method.
This complex was interacted with calf thymus DNA via positive cooperative interaction.
The fluorescence data indicates that Pd complex interact with ethidium bromide-DNA, were intercalate in DNA. These results were confirmed by circular dichroism spectra.