Background: Ventilator-associated pneumonia (VAP) is the most common cause of infection in patients admitted to the Intensive Care Unit (ICU). Efficient oral care using antiseptics may reduce the incidence of VAP. Thus, this study is designed to evaluate VAP preventing efficacy of Turmeric extract solution as an oral antiseptic natural product. Method: A total number of 115 admitted patients to the ICU department participated in this quasi-experimental trial and finally 80 intubated patients as two allocated groups of 40 cases were enrolled in the presented study. The case group received Turmeric extract mouthwash in addition to chlorhexidine and the control group received Chlorhexidine alone. Then, the incidence of VAP was determined using the Clinical Pulmonary Infection Score(CPIS) every three days all through two weeks, and fi,nally the resulting data were statistically analyzed to show how the effectiveness of the new approach. Results: The mean age of all participating patients was 37.58± 12.72. No significant difference was found in the VAP rate in the two groups of Turmeric and control (35% vs. 40 %, respectively, Pvalue=0.644). Furthermore, there were no statistically significant differences between Turmeric and control groups in the cases of Acute Physiology and Chronic Health Evaluation (APACHE) scores and intubation days as well as the clinical outcomes of patients. Conclusion: Us of Turmeric extract solution associated with Chlorhexidinedid is not significantly effective in the case of VAP prevention in comparison with Chlorhexidine alone.