This study was carried out in Kerman, Iran. Data about cardiovascular mortality was inquired from the Kerman city Health Authority and air pollution data was inquired from the Kerman Environmental Protection Agency from 2006 to 2011. The concentration of seven pollutants SO2, NO2, O3, CO, PM10, NOX, NO is measured daily in Kerman. The relation between mortality from cardiovascular diseases and air pollution was analyzed by using correlation and negative binomial regression. Statistical analysis showed that the only significant correlation observed was between ozone and female cardiovascular mortality (r = 0.31). With increase in ozone, the number of female cardiovascular deaths increased as well. But in both crude and adjusted negative binomial regression increase in pollutants was not associated with increased incidence of cardiovascular deaths. There was not a significant relation between air pollution and cardiovascular death in Kerman. More studies in cities with higher levels of pollutants are needed to assess the effects of pollutants on cardiovascular mortality.