Penetrating look at around world demonstrate this fact which today world is very different,compared with the past. This rapidly changing world has created a society craving for speed andaction. In this world of changing conditions and priorities, leaders and individuals contributors alike must be able to look beyond the now and take a more strategic leadership approach to their work and responsibilities. Without effective strategic leadership, the probability that anorganization can achieve superior or even satisfactory performance when confronting the challenges of the global economy will be greatly reduced. On the other hand with the increasingcompetition in a dynamic environment, competitive advantage can be very important to achievebetter performance and better results eventually. Entrepreneurship affects the competitive advantage through the organization capability, strategic decision making and innovationapplying to reach ultimate customers. In this research we first review the literature of strategicleadership and entrepreneurship, and then argue the relationship which strategic leadership could have with competitive advantage and organizational performance through entrepreneurship.